Telestrations is a HUGE favorite around here. It is so fun. It is basically the game Telephone (or Gossip) but drawn. It is hilarious.
I have to admit that we own all but one of the Ticket to Ride series. My husband and I love to play them.
My younger girls like Who Ate the Cake? (Clue junior), and Apples to Apples junior, Sorry, Life, Uno, and Old Maid.
My older girls like Scattergories, Clue, 221 Baker Street (Sherlock Holmes Clue type game), and Phase 10.
Other fun age spanning games are we like the Chronicles of Narnia and Herd Your Horses board games, Harry Potter Trivial Pursuit, and Apples to Apples, and occasionally, Pictopia.