I’m in the middle of my second son’s college app process. There is really no reason you need to stress or do anything terribly different for a science based kid going to college. You will want to find ways to document what he knows. No biggie. There are lots of options—community college or online classes, AP classes. Tests. Projects. Competitions. None are precluded by CM style learning. CM is an attitude, a way of approaching material. My oldest son is a physics major. My next is thinking of several things still, several hard and social sciences in the running. I sit down with my sons and we discuss and plan what they want to do, how we need to get there, preferred methods of learning and demonstrating and recording. All I can really suggest is get the CM series and read that, and get college-prep high school books and read those, and synthesize. You will often choose more literary materials, you may not do books with multiple choice quizzes after the chapters. But you can still use a math text, a science course or text.